The metabolic profiling of cheetahs (Acinonyx jubatus): A systems biology approach to understanding the chronic diseases they suffer in captivity
In captivity, cheetahs (Acinonyx jubatus) are known to suffer from several chronic diseases that do not occur in their wild-living counterparts. These include lymphoplasmacytic gastritis, glomerulosclerosis, renal amyloidosis, veno-occlusive disease of the liver, adrenal hyperplasia and several ill-defined neurological disorders. Many factors have been proposed as possibly being the cause of this phenomenon – factors such as stress, lack of exercise, low genetic variability and the provision of unnatural diets in captive facilities - but to date convincing pathophysiological explanations for these diseases have been lacking or unsatisfactory. Doctor Adrian Tordiffe investigated this problem using a systems biology approach – in other words, he attempted to understand as many of the components of the cheeatah’s metabolic system as possible.
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